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The peripheral blood smear, bone marrow biopsy, and aspirate findings were wnoju with immune thrombocytopenic purpura. The chromosome analysis revealed the 47,XXX karyotype. To the best of our knowledge, this is the first case report associated with the comorbidities of cerebral infarction, idiopathic thrombocytopenic purpura, and triple X syndrome. Kromozom incelemesinde 47,XXX karyotip tayin edildi. The cause of the disease is nondisjunction during the meiotic period and it is connected to advanced maternal age [ 2 ]. Pathophysiology of the disease is thought to be the destruction and impaired production of platelets by autoantibodies [ 3 ].

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Recent studies indicate that genes located on the X chromosome play a major and unique role in autoimmunity [ 4 ]. The number of X chromosomes and the consequently altered X-linked gene dosage are critical for the maintenance or the loss of immune tolerance [ 5 ]. ITP is usually associated with bleeding tendency, but it also has thrombotic complications, which have been reported Xxx sex in wonju rare intervals [ 367 ]. According to a recent large retrospective analysis, the incidence of thromboembolic events was 6. Recently, we experienced a case of cerebral infarction in a female ITP patient, and her karyotype revealed trisomy X.

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