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For most cell populations, there will be general agreement, no matter which definition is adopted, as to whether the cells are epithelial or not, but there will be differences in the classification of a few mostly minor cell types. In general, epithelial cells have characteristic methods of controlling their growth.

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Typically, there is a basement membrane with non-epithelial cells underneath it and a layer of epithelial cells on top of it. If the layer of epithelial cells is several cells deep, then the cells in contact with the membrane are called the basal layer of epithelial cells. The epithelial cells above the basal layer are moribund; they may or may not divide again, but they will ultimately be pushed up, out, and away to death by more cells moving up following mitoses in the basal layer. The ability of epithelial cells to divide is strongly influenced by contact with the basement membrane, and by the non-epithelial cells below it. To the extent to which the concept of a "stem cell" can be usefully carried over from reticuloendothelial kinetics to epithelial kinetics, all the epithelial stem cells probably lie in the basal layer, although some of the cells in the basal layer are not stem cells.

If there were stem cells elsewhere in the body capable of migrating to and colonizing the basal layer, this would be very relevant to cancer induction mechanisms, but no evidence exists either for such migratory epithelial stem cells or for migratory "control cells. The "topological" definition of what is epithelial and what is not is that all body surfaces which connect, however tortuously, with the outside of the body are epithelia, composed mainly of epithelial cells, and that nearly all human cells not on these surfaces are non-epithelial.

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